A new clinical trial is currently underway to discover whether or not CBD can relieve bone pain. Pure Green, a manufacturer of pharmaceutical-grade CBD pills, is sponsoring the analysis. Researchers will examine twenty participants to discover if a 5 mg sublingual tablet of CBD can alleviate their musculoskeletal pain.
This is another significant step in analyzing the consequences of CBD on the human skeleton. Musculoskeletal pain can result from a host of issues, but most specifically: fractures, dislocations, sprains, muscle tissue injury, and wear and tear.
People frequently treat bone pain with NSAIDS — anti-inflammatory ibuprofen drugs like Advil or Motrin.
The side effects of long-term ibuprofen use include heart attack, intestinal damage, and weaker bones — which does not bode well for patients already experiencing bone pain. Generally, these medications aren’t suitable for long-term use. But bone pain may be chronic, resulting in reduced activity, loss of sleep, and changes to one’s overall mood.
Cannabis is already an enticing option for pain treatment. The extensive chronic pain study financed by the National Institutes of Health proves this. CBD is becoming famous for its pain-relieving effects, especially with pain stemming from inflammation if CBD can also assist patients experiencing bone pain, which may be an impactful finding.
What We Already Know About CBD and Bone Pain
The endocannabinoid system helps preserve homeostasis throughout the whole body. Science has found that it also plays a part in keeping bones healthy. The two CB1 and CB2 receptors assist modulate the mechanisms involved in bone formation. Triggering these receptors can further help in bone formation and recovery procedures. Research also demonstrates that cannabis could potentially assist in curing fractured bones by triggering these receptors.
In a study published in the Journal of Bone and Mineral Research (2015), scientists discovered that CBD assisted bone recovery in laboratory rats. Not only did it make bones stronger, besides, but it also improved the growth of the collagenous matrix. This is important because the matrix provides the fundamental building blocks required to make new bone tissue.
Researchers discovered that CBD helps boost the dimensions of callous formation where fractures occur. This is a procedure where a cartilaginous callus mineralizes, and then bony callus simplifies it. This bony callus continues to form itself into the bone.
Another study published in the Annals of Medicine (2009), also discovered cannabinoids could help heal broken bones in rat models. Researchers indicated that cannabinoids might help treat, and maybe prevent, osteoporosis.
Helping Bones Heal and Cutting Down on Inflammation
Along with potentially assisting bones in repairing themselves, cannabis can also assist in the recovery process by maintaining inflammation at bay. Scientists have now long known that CBD functions as an anti-inflammatory. This implies cannabinoids can assist in preventing inflammatory conditions like rheumatoid arthritis.
Researchers have also found that by regulating the immune system, one can enhance the procedure for broken bone repair. Cannabis could help here too. Although the precise role of cannabinoids in modulation is not yet understood, studies indicate that cannabis could help immune system regulation. However, we need more research to determine whether or not cannabis modulates immune function in an ideal way.
How You Can Get Involved in this Clinical Trial
This new study by Pure Green is only getting started, with the objective of observing twenty participants. The current condition of the research is recruitment phase. This implies there is still time to get involved as a participant.
However, if you or somebody you know is experiencing musculoskeletal pain and might like to take part in this research, there are a couple of essential things to understand.
To connect, you can get in touch with investigators by phone or email. You may find contact info in the details of the research, alongside the inclusion and exclusion criteria.
The standards of this study further refine the hunt for participants to provide for superior control measures. Researchers are searching for participants who are suffering from mild to moderate musculoskeletal pain that surpasses a score of three on the Numeric Pain Rating Scale. The participant must also experience pain for ten days or more per month, for at least three months, before enrolling in the research.
Researchers may also be excluding anyone who is also taking medicine which affects the endocannabinoid system. The researchers in this research are attempting to learn if a specific CBD tablet helps prevent bone pain. This is why they require that participants only take the Pure Green tablets — no additional pain medications. This means the consumption of cannabis or any other sort of cannabinoid product is illegal during the research. The same goes for additional pain management pharmaceuticals.
For a complete list of the trial’s standards and get information, view the research details here.
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